Post-traumatic stress disorder (PTSD) is a mental and behavioral health condition that affects individuals who have endured a disturbing, distressing, and shocking event. People living with PTSD often include combat veterans, victims of sexual assault, child abuse, and domestic violence, and survivors of other forms of trauma (e.g., natural disaster, serious injury, etc.)

PTSD symptoms include: 

  • Flashbacks 
  • Harrowing dreams about the traumatic event 
  • Avoidant behavior 
  • A wide range of distressing physical and emotional symptoms 

Sadly, PTSD symptoms can be a lifelong ordeal for those afflicted with the condition due to the poor outcomes of traditional PTSD treatment. According to a 2016 study published in the Neuropsychopharmacology journal, symptoms of PTSD persist in up to 50% of patients who have undergone traditional treatment.

However, the future of PTSD treatment is bright. Ketamine for PTSD has gained traction in medical research circles and, in some instances, resulted in tentative mainstream adoption due to its efficacy. With an ever-growing mountain of evidence supporting the credentials of ketamine for PTSD treatment, conservative circles are finding it harder to ignore and dismiss.

Let’s explore PTSD in-depth — its causes, symptoms, and what makes it treatment resistant — as well as the improved outcomes of ketamine treatment.

What Is Post-Traumatic Stress Disorder or PTSD?

Per the American Psychiatric Association (APA), post-traumatic stress disorder is a psychiatric condition that affects individuals exposed to a traumatic event such as war, assault, natural disasters, serious injury, or accidents.

The APA classifies PTSD symptoms into four different categories:

  • Intrusion: It refers to the persistent flashback to traumatic memories. Patients who suffer from these intrusive thoughts, memories, and dreams often feel they are relieving the stressful event again. These symptoms cause immense psychological distress, pain, and suffering.
  • Avoidance: People with PTSD avoid contextual factors (e.g., places, people, objects) that may cause them to remember the incident and subsequently trigger an attack. Motor vehicle accident victims may avoid the street where their accident occurred or may avoid driving during the time of the day when it happened. Sexual assault victims often find it difficult to return to intimacy after their attack. Avoidant symptoms can lead to reduced social interactions and, eventually, isolation.
  • Changes in mood and cognition: Patients with PTSD are prone to a wide range of negative emotions, including depressive symptoms, anger, guilt, and shame. They can display symptoms similar to anxiety disorders, major depressive disorder, and other stress-related disorders. Some PTSD patients even turn to substance abuse to mitigate these negative emotions. According to a study by German and American researchers, 25-50% of sufferers of either PTSD or substance use disorder (SUD) have lifetime dual diagnoses of both conditions.
  • Changes in reactivity and alertness: A typical stress response in people with PTSD is increased reactivity and other behavioral symptoms. Due to their experiences with trauma, these individuals are increasingly sensitive, suspicious, and alert to external stimuli, often leading to outbursts and trouble with relaxation and sleeping. As per a study in the Psychiatry (Edgmont) journal, 44-90% of war veterans with PTSD have difficulty sleeping.

A combination of a truly awful set of symptoms and poor treatment outcomes makes ketamine for PTSD a no-brainer for those afflicted with this condition.

How Do Other Treatments Fare Against PTSD?

Traditional PTSD treatments range from pharmacological interventions to therapeutic-based treatments. However, the results of these treatments in easing the symptoms of PTSD are not stellar.

The U.S. Department of Veterans Affairs notes that only two drugs are currently approved by the U.S. Food and Drug Administration (FDA) for PTSD treatment: sertraline (Zoloft) and paroxetine (Paxil). Both are selective serotonin reuptake inhibitors (SSRIs), a popular class of antidepressants. However, some studies show that a relapse of symptoms occurs once a PTSD patient stops taking these drugs. 

Taking SSRIs and other antidepressants over a prolonged period can adversely affect one’s health. Research suggests that this medication can raise an individual’s risk of suffering a stroke and heart attack.

Supportive counseling, a traditional PTSD treatment, is ineffective in certain population groups. A UK study of around 2,000 participants found supportive counseling to have similar results to the waitlist control.

Trauma-focused cognitive behavioral therapy (TF-CBT), one of the leading traditional PTSD treatment options, is hindered by high dropout rates. Sleep problems often persist despite this treatment, and many patients do not experience a complete remission of symptoms.

It is no surprise, then, that ketamine for PTSD is especially appealing to patients with chronic PTSD or treatment-resistant symptoms.

How Does Ketamine Alleviate PTSD Symptoms?

While ketamine has shown extraordinary results in treating PTSD symptoms, the exact mechanisms of how it works are still the subject of intense study. Current research shows that ketamine modulates the neurotransmitter glutamate, thereby potentially reducing conditioned fear.

Individuals who have undergone treatment via ketamine for PTSD describe the drug’s ability to allow them to relive the experience in a safer and more controlled way. This approach allows them to take back their power and attenuate their fears.

Ketamine Success Rate Against Post-Traumatic Stress Disorder

A trial where ketamine treatment for PTSD was measured against the success of midazolam, a benzodiazepine used for sedation and the treatment of severe anxiety, was stopped early due to an enormous gap in efficacy between the two drugs (in favor of ketamine).

Furthermore, one study showed that patients treated with ketamine infusions for PTSD experienced a ~70% reduction in hospital admissions and readmissions. A randomized controlled trial also found that ketamine quickly achieved a reduction in PTSD symptoms following intravenous (IV) ketamine infusions.

How Safe Is Ketamine Infusion Therapy?

Ketamine is a safe and generally well-tolerated PTSD treatment. Many of the referenced studies note that the participants who received IV ketamine infusions for PTSD experienced little to no adverse reactions.

However, ketamine infusion therapy must be administered in a safe and professional setting (especially for PTSD patients) by a licensed physician. This approach ensures that any side effects of ketamine treatment that may arise during the infusion can be mitigated effectively.

Are You Ready To Start Your Ketamine Infusion Experience?

With mental health issues increasingly becoming the number one concern modern health advocates seek to solve, ketamine may just be that solution. But you don’t have to take just our word for it. Do your research, then come into Virginia’s premier ketamine infusion clinic in Leesburg.

Send us a message through our contact us page or call us at (571) 371-029 to connect with our friendly staff. Learn more about ketamine infusion therapies and their benefits for your health. If you’re ready for a one-on-one consultation, our office at 19490 Sandridge Way Suite 240, Lansdowne, Virginia 20176, proudly serves Loudoun County and the Ashburn area. Come in and let our experts create the best treatment plan for you. We also invite you to keep up with our blog and social media to get answers to many of the frequently asked questions about ketamine infusion therapies.

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Phone consultations only take about 15 minutes with a doctor from Virginia Infusion Therapies. Learn more about how ketamine solves for 70% of depression patients and can solve for you.