Major Depression

Virginia Infusion Therapies

Ketamine for Major Depression

Ketamine Infusion therapy has been shown to help reduce the symptoms Major Depression

Severe or Major Depression causes debilitating symptoms that interfere with a person’s life and well being. Standard treatments involve prescription medications that can have harmful side effects on the body and some are very addictive. For those patients, daily living can be excruciating and the prospect of facing the next day with the same symptoms can give them an overwhelming sense of helplessness. Luckily, there is a new treatment for Major Depression. Ketamine is that medication. Given IV, by a licensed and trained infusion specialist, Ketamine can severely reduce symptoms after the first treatment. And, you do not have to change current medications for this treatment to work. Ketamine has been shown to improve symptoms and allow patients to go back to their normal activities sooner and with more control of their symptoms.

Ketamine Infusion Therapy has been shown to Improve the Symptoms of Depression in up to 70% of Patients after even a Single Treatment

Depressed woman and Ketamine

Introduction to Ketamine for Major Depression

Patients with treatment resistant Major Depression are often desperate for relief from the feelings of sadness, lethargy, helplessness, and even suicidal thoughts. These patients have often tried months or years of medications that may have made them more tired, gain weight, or lead to other physical symptoms; talk therapy often doesn’t seem to help; and many patients have even tried electroconvulsive ECT therapy.

Ketamine is a big deal because it has been found to provide immediate relief in up to 70% of patients that have tried it. This includes patients with major depression, postpartum depression, severe anxiety, post-traumatic stress disorder, bipolar depression, and even pain conditions such as fibromyalgia. The most important point here is that Ketamine has the potential to provide immediate relief in patients that are desperate for any improvement of their mental and physical symptoms.


Why you should strongly consider Ketamine Infusions for your severe anxiety

Ketamine is a great medication because it has been found to provide immediate relief in up to 70% of patients that have tried it.  This includes patients with severe anxiety, major depression, postpartum depression, post-traumatic stress disorder, bipolar depression, and even pain conditions such as fibromyalgia.  Though, the relief is only short lived intitially, over time the effects last longer. And, once maintenance doses are achieved, patients say it is life changing.


A Major Breakthrough

Ketamine has the ability to treat some patients with even “treatment resistant” major depression in a matter of minutes! 70% of patients will see some improvement in their depressive symptoms after only a single infusion.

This improvement is temporary; but progressive improvement tends to be seen after several treatments. The immediate improvement after a Ketamine infusion is a a breakthrough, given that severely depressed patients have a much higher probability of self-harm and suicidal thoughts. Furthermore, patients such as those with postpartum depression require and benefit from rapid relief of their symptoms, so that can properly care for their infants.

Patients with treatment resistant depression understand that finding the right combination of medications can take months; many of the medications cause severe side effects such as decreased libido and weight gain.  Many of the newer medications are designed for patients with schizophrenia and can cause abnormal thoughts. Finally, many patients with treatment resistant depression will turn to electroconvulsive therapy (ECT) for relief, which carries a real risk of permanent memory loss.

In comparison, ketamine represents a major breakthrough in the treatment of depression, providing immediate relief with only minor side effects.  The side effects experienced usually occur only during the infusion session.  Studies have not shown longterm side effects from the dose strengths and frequency of infusions used to treat depressive and pain conditions.

You are a candidate if :

  • You have failed prescription antidepressants
  • You need the potential for immediate relief
  • Your symptoms are severe and intractable 

Schedule Your consultation

Please fill out the form below and a member of our team will get right back to you.  Once you fill out the form, you will also receive additional information back via email that helps explain your next steps

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How Does Ketamine Improve Severe Anxiety?

Researchers aren’t exactly sure the mechanism of how Ketamine infusion works to treat depression.  Ketamine works on many pathways and has been shown to help regenerate synaptic connections between brain cells that are damaged by stress and depression after even a single administration.

Ketamine is a drug that has been used by Anesthesiologists and Emergency Department Physicians for over 50 years to put patients to sleep for surgery or to sedate patients for minor procedures. It was noticed that some patients with depression or chronic pain felt better from their symptoms after their procedures. The relief was short-lived but the findings led to more research about how Ketamine infusion might be used to provide long-term relief for patients with depression or chronic pain.

respond to pain infusions

How many sessions should be done to determine if I will respond to pain infusions?

Ketamine infusion treatment is successful and immediate after only one treatment in about 70% of patients. The relief after the first treatment, however, can be only hours to days. Research has determined that the depression-relief can be extended like many drugs by increasing the number and dose of early treatments before determining a maintenance treatment regimen.

How Does Ketamine Work?

Researchers aren’t exactly sure the mechanism of how Ketamine infusions work, however it has been shown to help regenerate synaptic connections between brain cells that are damaged by stress, after even a single administration.  It is believed that at lower doses, Ketamine acts as a neurotransmitter antagonist ( GluN2B ) in the brain. This area of the brain is the focus of treatment for depression, anxiety, PTSD and chronic pain conditions.  Up to 70 % of patients treated with Ketamine for conditions ranging from Major Depression, Anxiety, PTSD, and chronic pain conditions show immediate improvement.  The immediate relief is in stark contrast to the slower methods of antidepressants medications and talk-therapy.  Ketamine is commonly used in the emergency room and operating rooms for anesthesia.  Read more on how you can take the first steps towards health and wellness.

Ketamine Molecule

Meet Your Doctors

jay kugler ketamine infusions

Jay Kugler, DO

Dr. Jay Kugler board certified in both Emergency Medicine and Family Medicine. He has worked as an Emergency Physician in Northern Virginia since 2002.  Dr. Kugler completed his undergraduate degree at San Diego State University, Osteopathic medical school at the University of North Texas HSC, and residency in Pontiac, Michigan. 

pranav virmani ketamine infusions

Pranav Virmani, MD

Dr. Pranav Virmani is a board certified Emergency Medicine physician who has been treating patients in Northern Virginia since 2002. He graduated medical school with Alpha Omega Alpha honors from Howard University Medical School and completed his residency at Christ Hospital and Medical Center in Emergency Medicine in 2002.

marwan jaber ketamine infusions

Marwan Jabber, MD

Dr. Marwan Jaber is a board certified Emergency Medicine physician in Northern Virginia since 2007. He earned his medical degree at SUNY Downstate in New York; and completed his residency in Emergency Medicine at Henry Ford Hospital in Detroit, Michigan. 

Some of Our Happy Customers

I can't tell you how happy I was that I found you guys. I was down to my last few wishes when I was told about Ketamine. It has saved my life!
I wanted to write and tell you that your clinic has changed my daughter's life. It has changed the lives of our whole family and we are extremely grateful. Nothing else worked to help Heidi feel better.

Other Depression Conditions

depressed woman

Major Depression



Ketamine Treatment for Postpartum Depression

Postpartum Depression

Severe Anxiety

Severe Anxiety

FAQs about your ketamine appointment

More FAQs about Ketamine

Some more information about your Ketamine Visit

Learn more about ketamine

30 minutes before first session to get paperwork done, answer any further questions and get setup for procedure.

15 minutes prior to subsequent sessions to answer any questions and set up for procedure.

You need to stop eating and drinking prior to your visit.  Stop all solid foods and non-clear liquids 4 hours prior to your procedure; stop all clear liquids 2 hours before your appointment.

We will review you chart, answer any further questions, place IV and monitor your vital signs.  Please make sure to use restroom prior to the infusion, as will not be able to get up and use bathroom, during the infusion, due to decreased coordination.  A urinal for men and a bedside commode for women will be available if necessary.

We will review you chart, answer any further questions, place IV and monitor your vital signs.  Please make sure to use restroom prior to the infusion, as will not be able to get up and use bathroom, during the infusion, due to decreased coordination.  A urinal for men and a bedside commode for women will be available if necessary.

Approximately 70% of patients will have improvement of their symptoms.  And, 10-30% can develop remission of their symptoms with continued treatment.


At this time, most insurance plans DO NOT cover Ketamine infusion therapy.  However, we will be happy to provide documentation of your visits, if you think your plan will cover this therapy. Virginia Infusion Therapies does not participate or bill insurance plans.

Yes.  Please continue with all of you current therapies and treatments while receiving Ketamine infusions.  Virginia Infusion Therapies provides only the infusion therapies you need for you condition.  Your primary care doctor, mental health provider, or other specialist will need to determine if your medications should be changed or discontinued.  Making changes without consulting primary care doctor, mental health provider, or other specialist will make it more difficult to control your symptoms and may disqualify you from further treatment at Virginia Infusion Therapies. We would be happy to correspond with your providers and coordinate your care.

Ketamine infusion therapy has been found to helpful in treating a variety of medical and mental health conditions including major depression, postpartum depression, anxiety, PTSD, migraine headaches, cluster headaches and fibromyalgia.

Ketamine was initially noticed in anecdotal reports from anesthesia cases. They noticed anxiety, depression and pain improvement for some of their patient who underwent anesthesia for other reasons.  Some patients with severe anxiety, depression or intractable pain would report they had, at least temporary relief, of their symptoms.  John Krystal, MD in the 1990s, now the chair of psychiatry at Yale, as well as other investigators began to study how Ketamine could affect the neurotransmitters in the brain.  They discovered that ketamine’s interactions with glutamate produced a rapid antidepressant effect in patients with major depressive disorders.  Prior to these studies, most efforts in the treatment of anxiety and depression focused on medications that controlled serotonin and norepinephrine. These medications continue to be used and are helpful in conjunction with Ketamine therapy.

When used by appropriately trained physicians, in the proper clinical setting, the answer is YES. However, Ketamine has a potential for adverse side effects, such an nausea, vomiting, rapid heart rate, transiently elevated blood pressure and temporary “out of body experience”. In the safe hand of an appropriately trained physician, these side effects can easily be managed.

Virginia Infusion Therapies’ Board Certified Emergency Physicians have the qualifications and training to administer Ketamine in a quiet, comfortable and safe environment. We are committed to you and your well being.

Ketamine is not designed to be a recreational drug, but like other medications used to treat diseases, has been abused as a recreational drug.  As a street drug, it has been used in doses much higher than those administered for therapeutic treatment of depression, other mental health diseases, and chronic pain.

When abused chronically and at high doses, Ketamine can become psychologically addictive. It has not been shown to be physically addictive.

However, when used at therapeutic doses, current data suggests that Ketamine to treat depression, other mental health conditions, and chronic pain may be used without any long term negative effects.  This makes it a viable treatment option for patients concerned about addiction, especially from chronic use of opiates, benzodiazepines, and other medications. In addition, there are no known long term negative side effects as with other medication used to treat these illnesses.

Ketamine can be given orally, intranasally, intramuscularly, and through intravenous routes. Studies have shown that a consistent steady state of ketamine levels only occurs through the intravenous route.  This is due to different absorption levels through the other routes. The lack of dependable absorption can effect how well ketamine works. 

Virginia Infusion Therapies

The First Ketamine Clinic in Northern Virginia

Virginia Infusion Therapies is one of the the first Ketamine Clinics in Northern Virginia, and the first clinic in Loudoun County to provide Ketamine infusion therapy for the treatment of Major Depression and Pain Conditions.  The clinic was established by four physicians in Loudoun who, through their professional experiences in medicine and their personal family experiences with depression, recognized that there are major problems in the recognition and treatment of depression.  They recognized that Major Depression, Post-Traumatic Stress Syndrome, and some pain conditions are often medical emergencies that requires treatments that are more effective…  and more effective IMMEDIATELY.